Article
Analysis of polymorphisms in AT-rich domains of neuregulin 1 gene in schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2006
Lachman Herbert M, Pedrosa Erika, Nolan Karen A, Glass Max, Ye Kenny, Saito Takuya
Abstract excerpt
Linkage analysis and association studies have pointed to neuregulin 1 (NRG1) as the prime candidate for 8p-linked schizophrenia (SZ). However, so far, no specific functional alleles in the gene's exons, intron-exon junctions and promoters have been identified that are unequivocally associated with SZ. In this study, we analyzed several NRG1 polymorphisms that affect ATTT motifs and AT-rich regions of the gene. We...
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