Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mercuric chloride inhibits the in vitro uptake of glutamate in GLAST- and GLT-1-transfected mutant CHO-K1 cells.

Biological trace element research - 1 Mar 2006

Mutkus Lysette, Aschner Judy L, Syversen Tore, Shanker Gouri, Sonnewald Ursula, Aschner Michael

Abstract excerpt

Glutamate is removed mainly by astrocytes from the extracellular fluid via high-affinity astroglial Na+ -dependent excitatory amino acid transporters, glutamate/aspartate transporter (GLAST), and glutamate transporter-1 (GLT-1). Mercuric chloride (HgCl2) is a highly toxic compound that inhibits glutamate uptake in astrocytes, resulting in excessive extracellular glutamate accumulation, leading to excitotoxicity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport
Share to CHO Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cricetinae

Share to Excitatory Amino Acid Transporter 2

Share to Glutamates

Share to In Vitro Techniques

Share to Sulfhydryl Compounds

Share to Transfection

Source

Identifiers

PMID: 16632895
DOI: 10.1385/BTER:109:3:267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mercuric chloride inhibits the in vitro uptake of glutamate in GLAST- and GLT-1-transfected mutant CHO-K1 cells.PMID 16632895Read ↗

Methylmercury alters the in vitro uptake of glutamate in GLAST- and GLT-1-transfected mutant CHO-K1 cells.Semantic proximity Read ↗

The in vitro uptake of glutamate in GLAST and GLT-1 transfected mutant CHO-K1 cells is inhibited by manganese.Semantic proximity Read ↗

Glutamate Excitotoxicity and NeurodegenerationSemantic proximity Read ↗

Increased internalisation and degradation of GLT-1 glial glutamate transporter in a cell model for familial amyotrophic lateral sclerosis (ALS).Semantic proximity Read ↗

Glutamate transport by retinal Muller cells in glutamate/aspartate transporter-knockout mice.Semantic proximity Read ↗

Thallium ions can replace both sodium and potassium ions in the glutamate transporter excitatory amino acid carrier 1.Semantic proximity Read ↗

Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1: lack of involvement of oxidative stress.Semantic proximity Read ↗

Effects of lipopolysaccharide on glial phenotype and activity of glutamate transporters: Evidence for delayed up-regulation and redistribution of GLT-1.Semantic proximity Read ↗

Non-essential roles of cysteine residues in functional expression and redox regulatory pathways for canine glutamate/aspartate transporter based on mutagenic analysis.Semantic proximity Read ↗

Impairment of glutamate transport and increased vulnerability to oxidative stress in neuroblastoma SH-SY5Y cells expressing a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

Upregulation of the glutamine transporter through transactivation mediated by cAMP/protein kinase A signals toward exacerbation of vulnerability to oxidative stress in rat neocortical astrocytes.Semantic proximity Read ↗

Ubiquitination-mediated internalization and degradation of the astroglial glutamate transporter, GLT-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.