Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development of Patient-specific AAV Vectors After Neutralizing Antibody Selection for Enhanced Muscle Gene Transfer.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Feb 2016

Li Chengwen, Wu Shuqing, Albright Blake, Hirsch Matthew, Li Wuping, Tseng Yu-Shan, Agbandje-McKenna Mavis, McPhee Scott, Asokan Aravind, Samulski R Jude

Abstract excerpt

A major hindrance in gene therapy trials with adeno-associated virus (AAV) vectors is the presence of neutralizing antibodies (NAbs) that inhibit AAV transduction. In this study, we used directed evolution techniques in vitro and in mouse muscle to select novel NAb escape AAV chimeric capsid mutants in the presence of individual patient serum. AAV mutants isolated in vitro escaped broad patient-specific NAb...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to Capsid Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dependovirus

Share to Gene Transfer Techniques

Share to Genetic Therapy

Share to Muscles

Share to Transduction, Genetic

Share to Viral Tropism

Source

Open in PubMed Open full text

Identifiers

PMID: 26220272
DOI: 10.1038/mt.2015.134
PMCID: PMC4754536

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development of Patient-specific AAV Vectors After Neutralizing Antibody Selection for Enhanced Muscle Gene Transfer.PMID 26220272Read ↗

Single Amino Acid Modification of Adeno-Associated Virus Capsid Changes Transduction and Humoral Immune ProfilesSemantic proximity Read ↗

Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across speciesSemantic proximity Read ↗

A Novel Triple-Mutant AAV6 Capsid Induces Rapid and Potent Transgene Expression in the Muscle and Respiratory Tract of MiceSemantic proximity Read ↗

Directed evolution of liver-detargeted AAV vectors for systemic gene delivery to skeletal muscle and heartSemantic proximity Read ↗

Rationally engineered novel AAV capsids for intra-articular gene deliverySemantic proximity Read ↗

A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selectionSemantic proximity Read ↗

Progress in Bioengineering of Myotropic Adeno-Associated Viral Gene Therapy VectorsSemantic proximity Read ↗

Novel Muscle-Tropic AAV Capsids with Dramatically Enhanced Transduction and Safety Profiles in Non-Human PrimatesSemantic proximity Read ↗

AI-designed AAV capsids deliver high-efficiency muscle gene transfer for low-dose therapySemantic proximity Read ↗

AAV vector development, back to the futureSemantic proximity Read ↗

Engineering novel AAV capsids by global de-targeting and subsequent muscle-specific tropism in mice and NHPsSemantic proximity Read ↗

Engineering novel AAV capsids by global de-targeting and subsequent muscle-specific tropism in mice and NHPsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.