Transgenic mice overexpressing neuropeptide Y in noradrenergic neurons: a novel model of increased adiposity and impaired glucose tolerance.

doi:10.2337/db07-0722

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Article

Transgenic mice overexpressing neuropeptide Y in noradrenergic neurons: a novel model of increased adiposity and impaired glucose tolerance.

Diabetes - 1 Jun 2008

Ruohonen Suvi T, Pesonen Ullamari, Moritz Niko, Kaipio Katja, Röyttä Matias, Koulu Markku, Savontaus Eriika

Abstract excerpt

OBJECTIVE: A functional polymorphism leucine 7 proline in the human neuropeptide Y (NPY) gene leading to increased NPY release from sympathetic nerves is associated with traits of metabolic syndrome. Although hypothalamic NPY neurons play an established role in promoting positive energy balance, the role of NPY colocalized with norepinephrine in sympathetic nervous system and brain noradrenergic neurons remains...

Topics

Adrenal Glands
Animals
Body Weight
Brain
DNA
Dopamine beta-Hydroxylase
Female
Genotype
Ghrelin
Glucose Intolerance
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Metabolic Syndrome

Mice

Mice, Inbred C57BL

Mice, Transgenic

Neurons

Neuropeptide Y

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 18276767
DOI: 10.2337/db07-0722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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