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Article

Agouti-related peptide plays a critical role in leptin's effects on female puberty and reproduction.

American journal of physiology. Endocrinology and metabolism - 1 Dec 2013

Sheffer-Babila Sharone, Sun Yan, Israel Davelene D, Liu Shun-Mei, Neal-Perry Genevieve, Chua Streamson C

Abstract excerpt

Deficient leptin signaling causes infertility via reduced activity of GnRH neurons, causing a hypogonadal state in both rodents and humans. Because GnRH neurons do not express leptin receptors, leptin's effect on GnRH neurons must be indirect. Neurons within the hypothalamic arcuate nucleus that coexpress AGRP and NPY are considered to be important intermediate neurons involved in leptin regulation of GnRH...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24169048
DOI: 10.1152/ajpendo.00241.2013
PMCID: PMC3882375

Genes

AGRP
NPY
ARC
FOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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