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Article

Interferon γ Repression of Collagen (COL1A2) Transcription Is Mediated by the RFX5 Complex

26 Nov 2003

Abstract excerpt

Interferon gamma (IFN-gamma) plays an important physiological role during inflammation by down-regulating collagen gene expression and activating major histocompatibility II (MHC-II) complex. The activation of MHC-II by IFN-gamma requires activation of a trimeric DNA binding transcriptional complex, RFX5 complex, containing RFXB (also called RFXANK or Tvl-1), RFXAP, as well as RFX5 protein. Previously, we...

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PMID: 12968017
DOI: 10.1074/jbc.m309003200

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Interferon γ Repression of Collagen (COL1A2) Transcription Is Mediated by the RFX5 ComplexPMID 12968017Read ↗

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