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Article

A competitive kinetic model of nucleic acid surface hybridization in the presence of point mutants.

Biophysical journal - 1 Feb 2006

Bishop J, Blair S, Chagovetz A M

Abstract excerpt

Microarray analysis has become increasingly complex due to the growing size of arrays and the inherent cross-binding of targets. In this work, we explore the effects of matched and mismatched target species concentrations, temperature, and the time of hybridization on sensing specificity in two-component systems. A finite element software is used to simulate the diffusion of DNA through a microfluidic chamber to...

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Identifiers

PMID: 16284267
DOI: 10.1529/biophysj.105.072314
PMCID: PMC1367108

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