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Article

Coulomb blockage of hybridization in two-dimensional DNA arrays.

Physical review. E, Statistical, nonlinear, and soft matter physics - 1 Oct 2002

Vainrub Arnold, Pettitt B Montgomery

Abstract excerpt

Experiments on DNA microarrays have revealed substantial differences in hybridization thermodynamics between DNA free in solution and surface tethered DNA. Here we develop a mean field model of the Coulomb effects in two-dimensional DNA arrays to understand the binding isotherms and thermal denaturation of the double helix. We find that the electrostatic repulsion of the assayed nucleic acid from the array of DNA...

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Identifiers

PMID: 12443233
DOI: 10.1103/PhysRevE.66.041905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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