Article
Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus.
Development (Cambridge, England) - 1 Dec 2005
Banizs Boglarka, Pike Martin M, Millican C Leigh, Ferguson William B, Komlosi Peter, Sheetz James, Bell Phillip D, Schwiebert Erik M, Yoder Bradley K
Abstract excerpt
Cilia are complex organelles involved in sensory perception and fluid or cell movement. They are constructed through a highly conserved process called intraflagellar transport (IFT). Mutations in IFT genes, such as Tg737, result in severe developmental defects and disease. In the case of the Tg737orpk mutants, these pathological alterations include cystic kidney disease, biliary and pancreatic duct abnormalities,...
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