Article
Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease.
Current biology : CB - 18 Sept 2007
Davenport James R, Watts Amanda J, Roper Venus C, Croyle Mandy J, van Groen Thomas, Wyss J Michael, Nagy Tim R, Kesterson Robert A, Yoder Bradley K
Abstract excerpt
The assembly of primary cilia is dependent on intraflagellar transport (IFT), which mediates the bidirectional movement of proteins between the base and tip of the cilium. In mice, congenic mutations disrupting genes required for IFT (e.g., Tg737 or the IFT kinesin Kif3a) are embryonic lethal, wh...
Topics
- Adiposity
- Animals
- Cilia
- Female
- Flagella
- Kidney
- Kidney Diseases, Cystic
- Kinesins
- Liver
- Male
- Mechanotransduction, Cellular
- Mice
- Mutation
- Obesity
- Pancreas
- Protein Transport