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Article

Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease.

Current biology : CB - 18 Sept 2007

Davenport James R, Watts Amanda J, Roper Venus C, Croyle Mandy J, van Groen Thomas, Wyss J Michael, Nagy Tim R, Kesterson Robert A, Yoder Bradley K

Abstract excerpt

The assembly of primary cilia is dependent on intraflagellar transport (IFT), which mediates the bidirectional movement of proteins between the base and tip of the cilium. In mice, congenic mutations disrupting genes required for IFT (e.g., Tg737 or the IFT kinesin Kif3a) are embryonic lethal, whereas kidney-specific disruption of IFT results in severe, rapidly progressing cystic pathology. Although the function...

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Identifiers

PMID: 17825558
DOI: 10.1016/j.cub.2007.08.034
PMCID: PMC2084209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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