Riding the wave of ependymal cilia: genetic susceptibility to hydrocephalus in primary ciliary dyskinesia.

Abstract excerpt

Congenital hydrocephalus is a relatively common and debilitating birth defect with several known physiological causes. Dysfunction of motile cilia on the ependymal cells that line the ventricular surface of the brain can result in hydrocephalus by hindering the proper flow of cerebrospinal fluid. As a result, hydrocephalus can be associated with primary ciliary dyskinesia, a rare pediatric syndrome resulting from...

Topics

• Animals
• Cilia
• Disease Models, Animal
• Ependyma
• Genetic Predisposition to Disease
• Humans
• Hydrocephalus
• Kartagener Syndrome
• Mice