Article
Population stratification confounds genetic association studies among Latinos.
Human genetics - 1 Jan 2006
Choudhry Shweta, Coyle Natasha E, Tang Hua, Salari Keyan, Lind Denise, Clark Suzanne L, Tsai Hui-Ju, Naqvi Mariam, Phong Angie, Ung Ngim, Matallana Henry, Avila Pedro C, Casal Jesus, Torres Alfonso, Nazario Sylvette, Castro Richard, Battle Natalie C, Perez-Stable Eliseo J, Kwok Pui-Yan, Sheppard Dean, Shriver Mark D, Rodriguez-Cintron William, Risch Neil, Ziv Elad, Burchard Esteban Gonzàlez
Abstract excerpt
In the United States, asthma prevalence and mortality are the highest among Puerto Ricans and the lowest among Mexicans. Case-control association studies are a powerful strategy for identifying genes of modest effect in complex diseases. However, studies of complex disorders in admixed populations such as Latinos may be confounded by population stratification. We used ancestry informative markers (AIMs) to...
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