Article
Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics.
Genetic epidemiology - 1 Jul 2005
Salari Keyan, Choudhry Shweta, Tang Hua, Naqvi Mariam, Lind Denise, Avila Pedro C, Coyle Natasha E, Ung Ngim, Nazario Sylvette, Casal Jesus, Torres-Palacios Alfonso, Clark Suzanne, Phong Angie, Gomez Ivan, Matallana Henry, Pérez-Stable Eliseo J, Shriver Mark D, Kwok Pui-Yan, Sheppard Dean, Rodriguez-Cintron William, Risch Neil J, Burchard Esteban González, Ziv Elad
Abstract excerpt
Genetic association studies in admixed populations may be biased if individual ancestry varies within the population and the phenotype of interest is associated with ancestry. However, recently admixed populations also offer potential benefits in association studies since markers informative for ancestry may be in linkage disequilibrium across large distances. In particular, the enhanced LD in admixed populations...
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