Article
Cell-specific regulation of androgen receptor phosphorylation in vivo.
The Journal of biological chemistry - 9 Dec 2005
Taneja Samir S, Ha Susan, Swenson Nicole K, Huang Hong Ying, Lee Peng, Melamed Jonathan, Shapiro Ellen, Garabedian Michael J, Logan Susan K
Abstract excerpt
The biological ramifications of phosphorylation of the androgen receptor (AR) are largely unknown. To examine the phosphorylation of AR at serine 213, a putative substrate for Akt, a phosphorylation site-specific antibody was generated. The use of this antibody indicated that AR Ser-213 is phosphorylated in vivo and that phosphorylation is tightly regulated in a cell type-specific manner. Furthermore, Ser-213...
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