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Article

Identification of kinases regulating prostate cancer cell growth using an RNAi phenotypic screen.

PloS one - 1 Jan 2012

Whitworth Hilary, Bhadel Shriti, Ivey Melissa, Conaway Mark, Spencer Andrea, Hernan Ronald, Holemon Heather, Gioeli Daniel

Abstract excerpt

As prostate cancer progresses to castration-resistant disease, there is an increase in signal transduction activity. Most castration-resistant prostate tumors continue to express the androgen receptor (AR) as well as androgen-responsive genes, despite the near absence of circulating androgen in these patients. The AR is regulated not only by its cognate steroid hormone, but also by interactions with a...

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Share to Androgens
Share to Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Prostatic Neoplasms

Share to Protein Kinases

Share to Real-Time Polymerase Chain Reaction

Share to Receptors, Androgen

Share to RNA, Small Interfering

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 22761715
DOI: 10.1371/journal.pone.0038950
PMCID: PMC3384611

Genes

CIT
DGKD
GALK2
PSKH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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