Specific combinations of donor and recipient KIR-HLA genotypes predict for large differences in outcome after cord blood transplantation.

doi:10.1182/blood-2016-03-706317

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Article

Specific combinations of donor and recipient KIR-HLA genotypes predict for large differences in outcome after cord blood transplantation.

Blood - 14 Jul 2016

Sekine Takuya, Marin David, Cao Kai, Li Li, Mehta Pramod, Shaim Hila, Sobieski Catherine, Jones Roy, Oran Betul, Hosing Chitra, Rondon Gabriela, Alsuliman Abdullah, Paust Silke, Andersson Borje, Popat Uday, Kebriaei Partow, Muftuoglu Muharrem, Basar Rafet, Kondo Kayo, Nieto Yago, Shah Nina, Olson Amanda, Alousi Amin, Liu Enli, Sarvaria Anushruti, Parmar Simrit, Armstrong-James Darius, Imahashi Nobuhiko, Molldrem Jeffrey, Champlin Richard, Shpall Elizabeth J, Rezvani Katayoun

Abstract excerpt

The ability of cord blood transplantation (CBT) to prevent relapse depends partly on donor natural killer (NK) cell alloreactivity. NK effector function depends on specific killer-cell immunoglobulin-like receptors (KIR) and HLA interactions. Thus, it is important to identify optimal combinations of KIR-HLA genotypes in donors and recipients that could improve CBT outcome. We studied clinical data, KIR and HLA...

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Identifiers

PMID: 27247137
DOI: 10.1182/blood-2016-03-706317
PMCID: PMC4946205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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