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Article

Targeting PRPK Function Blocks Colon Cancer Metastasis.

Molecular cancer therapeutics - 1 May 2018

Zykova Tatyana, Zhu Feng, Wang Lei, Li Haitao, Lim Do Young, Yao Ke, Roh Eunmiri, Yoon Sang-Pil, Kim Hong-Gyum, Bae Ki Beom, Wen Weihong, Shin Seung Ho, Nadas Janos, Li Yan, Ma Weiya, Bode Ann M, Dong Zigang

Abstract excerpt

The biological functions of the p53-related protein kinase (PRPK) remain unclear. We have previously demonstrated that PRPK is phosphorylated by the T-LAK cell-originated protein kinase (TOPK) and that phosphorylated PRPK (p-PRPK) promotes colon cancer metastasis. Here, we analyzed colon adenocarcinomas from 87 patients and found that higher expression levels of p-PRPK were associated with later stages of...

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Identifiers

PMID: 29483219
DOI: 10.1158/1535-7163.MCT-17-0628
PMCID: PMC5940014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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