Article
The myeloma stem cell concept, revisited: from phenomenology to operational terms.
Haematologica - 1 Dec 2016
Johnsen Hans Erik, Bøgsted Martin, Schmitz Alexander, Bødker Julie Støve, El-Galaly Tarec Christoffer, Johansen Preben, Valent Peter, Zojer Niklas, Van Valckenborgh Els, Vanderkerken Karin, van Duin Mark, Sonneveld Pieter, Perez-Andres Martin, Orfao Alberto, Dybkær Karen
Abstract excerpt
The concept of the myeloma stem cell may have important therapeutic implications, yet its demonstration has been hampered by a lack of consistency in terms and definitions. Here, we summarize the current documentation and propose single-cell in vitro studies for future translational studies. By the classical approach, a CD19-/CD45low/-/CD38high/CD138+ malignant plasma cell, but not the CD19+/CD38low/- memory B...
Topics
- Animals
- Antineoplastic Agents
- B-Lymphocytes
- Biomarkers
- Cell Plasticity
- Cell Self Renewal
- Drug Resistance, Neoplasm
- Genetic Variation
- Humans
- Multiple Myeloma
- Neoplastic Stem Cells
- Phenotype