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Article

Mesenchymal stromal cells revert multiple myeloma cells to less differentiated phenotype by the combined activities of adhesive interactions and interleukin-6.

Experimental cell research - 1 Jul 2009

Dezorella Nili, Pevsner-Fischer Meirav, Deutsch Varda, Kay Sigi, Baron Shoshana, Stern Ruth, Tavor Sigal, Nagler Arnon, Naparstek Elizabeth, Zipori Dov, Katz Ben-Zion

Abstract excerpt

Multiple myeloma is characterized by the malignant growth of immunoglobulin producing plasma cells, predominantly in the bone marrow. The effects of primary human mesenchymal stromal cells on the differentiation phenotype of multiple myeloma cells were studied by co-culture experiments. The incubation of multiple myeloma cells with bone marrow-derived mesenchymal stromal cells resulted in significant reduction of...

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PMID: 19328780
DOI: 10.1016/j.yexcr.2009.03.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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