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Article

Systematic intervention of transcription for identifying network response to disease and cellular phenotypes.

Bioinformatics (Oxford, England) - 1 Jan 2006

Li Huai, Zhan Ming

Abstract excerpt

MOTIVATION: A major challenge in post-genomic research has been to understand how physiological and pathological phenotypes arise from the networks of expressed genes. Here, we addressed this issue by developing an algorithm to mimic the behavior of regulatory networks in silico and to identify the dynamic response to disease and changing cellular conditions. RESULTS: With regulatory pathway and gene expression...

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PMID: 16278241
DOI: 10.1093/bioinformatics/bti752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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