Article
Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy.
Oncotarget - 20 Apr 2015
Nitzki Frauke, Tolosa Ezequiel J, Cuvelier Nicole, Frommhold Anke, Salinas-Riester Gabriela, Johnsen Steven A, Fernandez-Zapico Martin E, Hahn Heidi
Abstract excerpt
Mice with heterozygous loss of the tumor suppressor Patched1 (Ptch) develop rhabdomyosarcoma (RMS)-like tumors. However, Ptch transcripts are consistently overexpressed in these tumors. We have recently shown that the upregulated transcripts are derived from the mutated Ptch allele thus leading to the hypothesis that the wild-type allele is repressed during RMS development. Here we describe epigenetic changes...
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