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Article

Exendin-4 enhances insulin-positive phenotype of human pluripotent stem cell-derived β cells during transplantation.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Oct 2025

Crumley Kelly M, Bealer Elizabeth J, Lietzke Anne C, Soleimanpour Scott A, Shea Lonnie D

Abstract excerpt

An emerging technique for the treatment of type 1 diabetes, which is characterized by hyperglycemia resulting from the loss of insulin-secreting β cells, involves transplantation of human pluripotent stem cell (hPSC)-derived β cells. This transplantation procedure can induce normoglycemia, yet the efficiency of cell survival and function post transplantation remain opportunities for improvement. Here, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40676832
DOI: 10.1016/j.ymthe.2025.07.015
PMCID: PMC12324850

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PLG

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