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Article

Exendin-4 Promotes Beta Cell Proliferation via PI3k/Akt Signalling Pathway

1 Jan 2015

Abstract excerpt

BACKGROUND/AIMS: Prevention of diabetes requires maintenance of a functional beta-cell mass, the postnatal growth of which depends on beta cell proliferation. Past studies have shown evidence of an effect of an incretin analogue, Exendin-4, in promoting beta cell proliferation, whereas the underlying molecular mechanisms are not completely understood. METHODS: Here we studied the effects of Exendin-4 on beta cell...

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PMID: 25895469
DOI: 10.1159/000374027

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