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Article

High dosage of Exendin-4 increased early insulin secretion in differentiated beta cells from mouse embryonic stem cells.

Acta pharmacologica Sinica - 1 May 2010

Li Hua, Lam Amy, Xu Ai-min, Lam Karen Sl, Chung Sookja Kim

Abstract excerpt

AIM: To investigate early insulin release (EIR) and late insulin release (LIR) upon glucose challenge as well as important insulin signaling factors in differentiated insulin-producing cells from embryonic stem cells(ESCs). METHODS: A recently published protocol was modified by increasing the concentration of Exendin-4 (from 0.1 nmol/L to 10 nmol/L) together with an additional 5-day culture in low glucose (5.5...

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Identifiers

PMID: 20418895
DOI: 10.1038/aps.2010.38
PMCID: PMC4002753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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