Article
Further evidence for LBP-1c/CP2/LSF association in Alzheimer's disease families.
Journal of medical genetics - 1 Nov 2005
Bertram L, Parkinson M, McQueen M B, Mullin K, Hsiao M, Menon R, Moscarillo T J, Blacker D, Tanzi R E
Abstract excerpt
OBJECTIVES: Several studies suggested chromosome 12 harbours an Alzheimer's disease (AD) risk factor gene. Significant association of a single nucleotide polymorphism (SNP) in the 3' UTR of transcription factor CP2 (LBP-1c/CP2/LSF or TFCP2) at 12q13 was reported in three independent case-control studies, but no family based analyses have been performed to date. METHODS: Genotypes for three SNPs were generated in...
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