Article
Age-dependent 6kb deletion in human liver mitochondrial DNA.
Biochemistry international - 1 Mar 1992
Yen T C, Pang C Y, Hsieh R H, Su C H, King K L, Wei Y H
Abstract excerpt
Using PCR technique, restriction mapping and DNA sequencing, we analyzed liver mitochondrial DNA (mtDNA) of 2 stillborn babies and 62 Chinese subjects with non-liver disease from 27 to 86 years old. The results showed an age-dependent 6,063 bp deletion in the liver mtDNA of older subjects. We fou...
Topics
- Adult
- Aged
- Aged, 80 and over
- Aging
- Base Sequence
- DNA, Mitochondrial
- Fetal Death
- Humans
- Middle Aged
- Mitochondria, Liver
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Restriction Mapping