A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids.

Abstract excerpt

Paraoxonase-1 (PON1), an enzyme that metabolizes organophosphate insecticides, is secreted by the liver and transported in the blood complexed to HDL. In humans and mice, low plasma levels of PON1 have also been linked to the development of atherosclerosis. We previously reported that hepatic Pon1 expression was decreased when C57BL/6J mice were fed a high-fat, high-cholesterol diet supplemented with cholic acid...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Anthracenes
• Share to Bile Acids and Salts