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Article

Transcriptional regulation of human Paraoxonase 1 by nuclear receptors.

Chemico-biological interactions - 25 Apr 2017

Ponce-Ruiz N, Murillo-González F E, Rojas-García A E, Mackness Mike, Bernal-Hernández Y Y, Barrón-Vivanco B S, González-Arias C A, Medina-Díaz I M

Abstract excerpt

Paraoxonase 1 (PON1) is a calcium-dependent lactonase synthesized primarily in the liver and secreted into the plasma, where it is associates with high density lipoproteins (HDL). PON1 acts as antioxidant preventing low-density lipoprotein (LDL) oxidation, a process considered critical in the initiation and progression of atherosclerosis. Additionally, PON1 hydrolyzes and detoxifies some toxic metabolites of...

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Source

Identifiers

PMID: 28223025
DOI: 10.1016/j.cbi.2017.02.005

Genes

PON1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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