Article
Proteolytic cleavage of covalently linked cell wall proteins by Candida albicans Sap9 and Sap10.
Eukaryotic cell - 1 Jan 2011
Schild Lydia, Heyken Antje, de Groot Piet W J, Hiller Ekkehard, Mock Marlen, de Koster Chris, Horn Uwe, Rupp Steffen, Hube Bernhard
Abstract excerpt
The cell wall of the human-pathogenic fungus Candida albicans is a robust but also dynamic structure which mediates adaptation to changing environmental conditions during infection. Sap9 and Sap10 are cell surface-associated proteases which function in C. albicans cell wall integrity and interaction with human epithelial cells and neutrophils. In this study, we have analyzed the enzymatic properties of Sap9 and...
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