Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse.

Development (Cambridge, England) - 1 Dec 2005

Kawauchi Shimako, Shou Jianyong, Santos Rosaysela, Hébert Jean M, McConnell Susan K, Mason Ivor, Calof Anne L

Abstract excerpt

In vertebrate olfactory epithelium (OE), neurogenesis proceeds continuously, suggesting that endogenous signals support survival and proliferation of stem and progenitor cells. We used a genetic approach to test the hypothesis that Fgf8 plays such a role in developing OE. In young embryos, Fgf8 RNA is expressed in the rim of the invaginating nasal pit (NP), in a small domain of cells that overlaps partially with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryonic Development
Share to Fibroblast Growth Factor 8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Mice, Mutant Strains

Share to Morphogenesis

Share to Nasal Cavity

Share to Neurons

Share to Stem Cells

Source

Identifiers

PMID: 16267092
DOI: 10.1242/dev.02143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse.PMID 16267092Read ↗

FGF signaling through FGFR1 is required for olfactory bulb morphogenesis.Semantic proximity Read ↗

Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules.Semantic proximity Read ↗

SP8 regulates signaling centers during craniofacial development.Semantic proximity Read ↗

Differential requirements for FGF3, FGF8 and FGF10 during inner ear development.Semantic proximity Read ↗

Fgf8 and Fgf3 are required for zebrafish ear placode induction, maintenance and inner ear patterning.Semantic proximity Read ↗

Fgf3 and Fgf10 are required for mouse otic placode induction.Semantic proximity Read ↗

A SHH-responsive signaling center in the forebrain regulates craniofacial morphogenesis via the facial ectodermSemantic proximity Read ↗

Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal DysplasiaSemantic proximity Read ↗

Deletion of OTX2 in neural ectoderm delays anterior pituitary development.Semantic proximity Read ↗

Fgf8is required for anterior heart field developmentSemantic proximity Read ↗

Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11.Semantic proximity Read ↗

Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.