Article
Dextran-shelled oxygen-loaded nanodroplets reestablish a normoxia-like pro-angiogenic phenotype and behavior in hypoxic human dermal microvascular endothelium.
Toxicology and applied pharmacology - 1 Nov 2015
Basilico Nicoletta, Magnetto Chiara, D'Alessandro Sarah, Panariti Alice, Rivolta Ilaria, Genova Tullio, Khadjavi Amina, Gulino Giulia Rossana, Argenziano Monica, Soster Marco, Cavalli Roberta, Giribaldi Giuliana, Guiot Caterina, Prato Mauro
Abstract excerpt
In chronic wounds, hypoxia seriously undermines tissue repair processes by altering the balances between pro-angiogenic proteolytic enzymes (matrix metalloproteinases, MMPs) and their inhibitors (tissue inhibitors of metalloproteinases, TIMPs) released from surrounding cells. Recently, we have shown that in human monocytes hypoxia reduces MMP-9 and increases TIMP-1 without affecting TIMP-2 secretion, whereas in...
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