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Article

Synergistic effects of PDGF-BB and cAMP-elevating agents on expression of connexin43 in mesangial cells.

American journal of physiology. Renal physiology - 1 May 2006

Yao Jian, Kitamura Masanori, Zhu Ying, Meng Yiman, Kasai Ayumi, Hiramatsu Nobuhiko, Morioka Tetsuo, Takeda Masayuki, Oite Takashi

Abstract excerpt

The gap junction plays an important role in the regulation of cell growth, migration, and differentiation. Platelet-derived growth factor (PDGF) is reported to be a potent inhibitor of gap junctional intercellular communication (GJIC). Short-term exposure of cells to PDGF causes rapid and transient disruption of GJIC without altering connexin43 (Cx43) protein level. In this study, we investigated long-term...

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PMID: 16263806
DOI: 10.1152/ajprenal.00134.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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