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Article

PDGF-BB enhances alpha1beta1 integrin-mediated activation of the ERK/AP-1 pathway involved in collagen matrix remodeling by rat mesangial cells.

Journal of cellular physiology - 1 Mar 2004

Kagami Shoji, Urushihara Maki, Kitamura Akiko, Kondo Shuji, Hisayama Tetsuhiro, Kitamura Masanori, Löster Klemens, Reutter Werner, Kuroda Yasuhiro

Abstract excerpt

Platelet-derived growth factor-BB (PDGF-BB) has been implicated in the pathogenesis of progressive glomerulonephritis (GN). Previous studies have reported that PDGF-BB stimulates mesangial cells (MCs)-induced collagen matrix remodeling through enhancement of alpha1beta1 integrin-dependent migratory activity. To determine the cell signaling pathway responsible for abnormal MC-related mesangial matrix remodeling in...

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Identifiers

PMID: 14755552
DOI: 10.1002/jcp.10433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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