Article
Establishment and maintenance of planar epithelial cell polarity by asymmetric cadherin bridges: a computer model.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jan 2006
Le Garrec Jean-François, Lopez Philippe, Kerszberg Michel
Abstract excerpt
Animal scales, hairs, feathers, and cilia are oriented due to cell polarization in the epithelial plane. Genes involved have been identified, but the signal and mechanism remain unknown. In Drosophila wing polarization, the action of a gradient of Frizzled activity is widely assumed; and cell-cell signalling by cadherins such as Flamingo surely plays a major role. We present a computer model where reading the...
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