Article
Cell packing influences planar cell polarity signaling.
Proceedings of the National Academy of Sciences of the United States of America - 2 Dec 2008
Ma Dali, Amonlirdviman Keith, Raffard Robin L, Abate Alessandro, Tomlin Claire J, Axelrod Jeffrey D
Abstract excerpt
Some epithelial cells display asymmetry along an axis orthogonal to the apical-basal axis, referred to as planar cell polarity (PCP). A Frizzled-mediated feedback loop coordinates PCP between neighboring cells, and the cadherin Fat transduces a global directional cue that orients PCP with respect to the tissue axes. The feedback loop can propagate polarity across clones of cells that lack the global directional...
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