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Article

Mathematical modeling of planar cell polarity to understand domineering nonautonomy.

Science (New York, N.Y.) - 21 Jan 2005

Amonlirdviman Keith, Khare Narmada A, Tree David R P, Chen Wei-Shen, Axelrod Jeffrey D, Tomlin Claire J

Abstract excerpt

Planar cell polarity (PCP) signaling generates subcellular asymmetry along an axis orthogonal to the epithelial apical-basal axis. Through a poorly understood mechanism, cell clones that have mutations in some PCP signaling components, including some, but not all, alleles of the receptor frizzled, cause polarity disruptions of neighboring wild-type cells, a phenomenon referred to as domineering nonautonomy. Here,...

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Identifiers

PMID: 15662015
DOI: 10.1126/science.1105471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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