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Article

Hysteresis of butyrylcholinesterase in the approach to steady-state kinetics.

Chemico-biological interactions - 15 Dec 2005

Masson Patrick, Schopfer Lawrence M, Froment Marie-Thérèse, Debouzy Jean-Claude, Nachon Florian, Gillon Emilie, Lockridge Oksana, Hrabovska Anna, Goldstein Boris N

Abstract excerpt

Butyrylcholinesterase (BChE) displays hysteretic behavior with certain neutral and charged substrates in the approach to steady state. Previous studies led us to interpret this phenomenon in terms of slow transitions between two enzyme conformers E and E'. This kinetic peculiarity is observed in human, horse and rat BChE. Oscillations that superimpose on the hysteretic lag are observed when benzoylcholine and...

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Identifiers

PMID: 16256969
DOI: 10.1016/j.cbi.2005.10.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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