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Article

The butyrylcholinesterase K variant confers structurally derived risks for Alzheimer pathology.

The Journal of biological chemistry - 19 Jun 2009

Podoly Erez, Shalev Deborah E, Shenhar-Tsarfaty Shani, Bennett Estelle R, Ben Assayag Einor, Wilgus Harvey, Livnah Oded, Soreq Hermona

Abstract excerpt

The K variant of butyrylcholinesterase (BChE-K, 20% incidence) is a long debated risk factor for Alzheimer disease (AD). The A539T substitution in BChE-K is located at the C terminus, which is essential both for BChE tetramerization and for its capacity to attenuate beta-amyloid (Abeta) fibril fo...

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Identifiers

PMID: 19383604
DOI: 10.1074/jbc.M109.004952
PMCID: PMC2719355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19383604-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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