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Article

Concentration-dependent reversible activation-inhibition of human butyrylcholinesterase by tetraethylammonium ion.

European journal of biochemistry - 1 Feb 2002

Stojan Jure, Golicnik Marko, Froment Marie-Thérèse, Estour Francois, Masson Patrick

Abstract excerpt

Tetraalkylammonium (TAA) salts are well known reversible inhibitors of cholinesterases. However, at concentrations around 10 mm, they have been found to activate the hydrolysis of positively charged substrates, catalyzed by wild-type human butyrylcholinesterase (EC 3.1.1.8) [Erdoes, E.G., Foldes, F.F., Zsigmond, E.K., Baart, N. & Zwartz, J.A. (1958) Science 128, 92]. The present study was undertaken to determine...

Topics

Animals
Butyrylcholinesterase
Butyrylthiocholine
Catalytic Domain
Cholinesterase Inhibitors
Computer Simulation
Enzyme Activation
Horses
Humans
Models, Chemical
Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Recombinant Proteins

Tetraethylammonium

Torpedo

Source

Identifiers

PMID: 11856351
DOI: 10.1046/j.1432-1033.2002.02749.x

Genes

BTC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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