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Article

Characterization of four BCHE mutations associated with prolonged effect of suxamethonium.

The pharmacogenomics journal - 1 Apr 2021

Brazzolotto Xavier, Courcelle Sébastien, Sauvanet Christophe, Guillon Virginia, Igert Alexandre, Kononchik Joseph, Nachon Florian, Ceppa Franck, Delacour Hervé

Abstract excerpt

Butyrylcholinesterase (BChE) deficiency is characterized by prolonged apnea after the use of muscle relaxants (suxamethonium or mivacurium) in patients who have mutations in the BCHE gene. Here, we report the characterization of four BCHE mutations associated with prolonged effect of suxamethonium (amino acid numbering based on the matured enzyme): p.20delValPheGlyGlyThrValThr, p.Leu88His, p.Ile140del and...

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Identifiers

PMID: 33024248
DOI: 10.1038/s41397-020-00192-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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