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Model of Human Butyrylcholinesterase Tetramer by Homology Modeling and Dynamics Simulation

9 Apr 2009

Abstract excerpt

A mutant of human butyrylcholinesterase (BChE) with high activity against cocaine would be highly promising as a drug for therapeutic treatment of cocaine abuse and overdose. It is desirable to design a recombinant BChE mutant with a long half-life in human circulation. Studies showed that BChE subunits can be assembled by a peptide containing the proline-rich attachment domain (PRAD) to form a stable tetramer....

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PMID: 19402731
DOI: 10.1021/jp8114995

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