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Article

HMGCoA reductase potentiates hedgehog signaling in Drosophila melanogaster.

Developmental cell - 1 Nov 2005

Deshpande Girish, Schedl Paul

Abstract excerpt

Drosophila HMGCoA reductase (hmgcr) catalyzes the biosynthesis of a mevalonate precursor for isoprenoids and has been implicated in the production of a signal by the somatic gonadal precursor cells (SGPs) that attracts migrating germ cells. Here, we show that hmgcr functions in the hedgehog (hh) signaling pathway. When hmgcr activity is reduced, high levels of Hh accumulate in hh-expressing cells in each...

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Source

Identifiers

PMID: 16256738
DOI: 10.1016/j.devcel.2005.09.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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