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Article

Functional analysis of Niemann-Pick disease type C family protein, NPC1a, in Drosophila melanogaster

15 May 2019

Abstract excerpt

ABSTRACT During embryonic gonad coalescence, primordial germ cells (PGCs) follow a carefully choreographed migratory route circumscribed by guidance signals towards somatic gonadal precursor cells (SGPs). In Drosophila melanogaster, SGP-derived Hedgehog (Hh), which serves as a guidance cue for the PGCs, is potentiated by mesodermally restricted HMGCoA-reductase (Hmgcr) and the ABC transporter...

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PMID: 31092503
DOI: 10.1242/dev.168427

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