Article
Inhibition of the 3-hydroxy-3-methyl-glutaryl-CoA reductase induces orofacial defects in zebrafish.
Birth defects research. Part A, Clinical and molecular teratology - 1 Oct 2016
Signore Iskra A, Jerez Carolina, Figueroa Diego, Suazo José, Marcelain Katherine, Cerda Oscar, Colombo Flores Alicia
Abstract excerpt
BACKGROUND: Orofacial clefts (OFCs) are common birth defects, which include a range of disorders with a complex etiology affecting formation of craniofacial structures. Some forms of syndromic OFCs are produced by defects in the cholesterol pathway. The principal enzyme of the cholesterol pathway is the 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR). Our aim is to study whether defects of HMGCR function would...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.