Article
HMG-CoA reductase guides migrating primordial germ cells.
Nature - 3 Dec 1998
Van Doren M, Broihier H T, Moore L A, Lehmann R
Abstract excerpt
The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is best known for catalysing a rate-limiting step in cholesterol biosynthesis, but it also participates in the production of a wide variety of other compounds. Some clinical benefits attributed to inhibitors of HMG-CoA reductase are now thought to be independent of any serum cholesterol-lowering effect. Here we describe a new...
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