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Article

A mutation in zebrafish hmgcr1b reveals a role for isoprenoids in vertebrate heart-tube formation.

Current biology : CB - 6 Feb 2007

D'Amico Leonard, Scott Ian C, Jungblut Benno, Stainier Didier Y R

Abstract excerpt

In vertebrates, the morphogenetic assembly of the primitive heart tube requires the medial migration and midline fusion of the bilateral myocardial epithelia. Several mutations that result in abnormal heart-tube formation have been studied; however, an understanding of the underlying molecular and cellular mechanisms of the migration and fusion of these epithelial sheets is far from complete. In a forward genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17276918
DOI: 10.1016/j.cub.2006.12.023

Genes

HMGCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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