Article
CARD15: a pleiotropic autoimmune gene that confers susceptibility to psoriatic arthritis.
American journal of human genetics - 1 Sept 2003
Rahman P, Bartlett S, Siannis F, Pellett F J, Farewell V T, Peddle L, Schentag C T, Alderdice C A, Hamilton S, Khraishi M, Tobin Y, Hefferton D, Gladman D D
Abstract excerpt
A recent genomewide scan in psoriatic arthritis (PsA) revealed a susceptibility locus at 16q. This region overlaps CARD15, a susceptibility gene in Crohn disease. The possibility of a common susceptibility gene between PsA and Crohn disease is further supported by epidemiological studies that note an increased incidence of psoriasis in subjects with Crohn. We screened 187 patients with PsA and 136 healthy...
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