Article
Carriers of the frequent lipoprotein lipase S447X variant exhibit enhanced postprandial apoprotein B-48 clearance.
Metabolism: clinical and experimental - 1 Nov 2005
Nierman Melchior C, Rip Jaap, Kuivenhoven Jan-Albert, van Raalte Daniel H, Hutten Barbara A, Sakai Naohiko, Kastelein John J P, Stroes Erik S G
Abstract excerpt
The frequent lipoprotein lipase S447X variant (LPLS447X) is firmly associated with a lower incidence of cardiovascular disease, the mechanisms for which remain to be established. To further unravel these beneficial effects, we studied the consequences of LPLS447X heterozygosity on LPL mass and activity, as well as on the postprandial lipoprotein profile. Fifteen male heterozygous LPLS447X carriers and 15 matched...
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