Article
Association between lipoprotein lipase (LPL) gene and blood lipids: a common variant for a common trait?
Genetic epidemiology - 1 May 2003
Morabia Alfredo, Cayanis Eftihia, Costanza Michael C, Ross Barbara M, Bernstein Martine S, Flaherty Maria Sol, Alvin Gabriela B, Das Kamna, Morris Michael A, Penchaszadeh Graciela K, Zhang Peizen, Gilliam T Conrad
Abstract excerpt
S447X, a serine substitution by a stop codon on base 99 of exon 9 of the lipoprotein lipase (LPL) gene, has beneficial effects on blood lipids. Other LPL alleles are associated with lipid levels, but whether one of these variants predominates remains elusive. We performed a systematic survey to identify single-nucleotide polymorphisms (SNPs) in all 10 LPL exons and flanking regions by resequencing the gene in 95...
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