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Article

Essential roles in development and pigmentation for the Drosophila copper transporter DmATP7.

Molecular biology of the cell - 1 Jan 2006

Norgate Melanie, Lee Esther, Southon Adam, Farlow Ashley, Batterham Philip, Camakaris James, Burke Richard

Abstract excerpt

Defects in the mammalian Menkes and Wilson copper transporting P-type ATPases cause severe copper homeostasis disease phenotypes in humans. Here, we find that DmATP7, the sole Drosophila orthologue of the Menkes and Wilson genes, is vital for uptake of copper in vivo. Analysis of a DmATP7 loss-of-function allele shows that DmATP7 is essential in embryogenesis, early larval development, and adult pigmentation and...

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Identifiers

PMID: 16251357
DOI: 10.1091/mbc.e05-06-0492
PMCID: PMC1345683

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